how to have room by room heating control with radiators?

Manifold is available for the rads too with individual actuator heads. If individual rooms must be controlled separately. It will be the most expensive but best solution. Try do not use 10mm diameter pipes go for 15mm - will not be blocked by sludge. Or programmable radiator thermostatic valves on each rads (Drayton Wiser) - I don't know much about them. Individual flow with zoning valved or (another name) two port valves and return keep separately up to the boiler. If it is enough to separate 1st & 2nd floor. Room stats could be in stair case landings. Top floor thermostat could give false readings affected by heat comming from below. Multi channel programmer needed for it.